Infrapopliteal lesion morphology in patients with critical limb ischemia: implications for the development of anti-restenosis technologies

Baumann, Frederic; Engelberger, Rolf Peter; Willenberg, Torsten Andreas; Do, Dai-Do; Kalka, Christoph; Baumgartner, Iris; Diehm, Nicolas Alexander (2013). Infrapopliteal lesion morphology in patients with critical limb ischemia: implications for the development of anti-restenosis technologies. Journal of endovascular therapy, 20(2), pp. 149-56. Phoenix, Ariz.: International Society of Endovascular Specialists 10.1583/1545-1550-20.2.149

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Purpose : To angiographically evaluate infrapopliteal arterial lesion morphology in a consecutive series of patients presenting with critical limb ischemia (CLI) and undergoing infrapopliteal angioplasty. Methods : A prospective analysis was undertaken of a consecutive series of CLI patients undergoing endovascular therapy in a tertiary referral center in the year 2011. Morphological assessment of baseline angiograms obtained prior to revascularization included lesion length, assessment of calcification using a semi-quantitative scoring system, and reference vessel diameter (RVD) measurement. Delta RVDs were assessed subtracting distal RVDs from proximal RVDs. A total of 197 infrapopliteal lesions in 105 CLI patients (n=106 limbs) were assessed. Of these, 136 lesions were treated by endovascular means. Results : The average length of treated lesions was 87.1±43.8 mm in stenoses and 124.0±78.3 mm in chronic occlusions (p<0.001). Mean RVD proximal to the lesions was 1.88 mm whereas it was 1.66 mm distal to the lesions (p≤0.03). Mean arterial calcification was 1.15. Conclusion : This prospective angiographic series underlines the complex nature and extensive longitudinal involvement of infrapopliteal lesions in CLI patients. These findings should be taken into consideration for anti-restenosis concepts in this challenging subgroup of peripheral artery disease patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Engelberger, Rolf Peter; Willenberg, Torsten Andreas; Do, Dai-Do; Baumgartner, Iris and Diehm, Nicolas Alexander

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1526-6028

Publisher:

International Society of Endovascular Specialists

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

07 Jul 2014 14:53

Publisher DOI:

10.1583/1545-1550-20.2.149

PubMed ID:

23581754

Web of Science ID:

000317996800004

URI:

https://boris.unibe.ch/id/eprint/14138 (FactScience: 220975)

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