Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure

Boscan, P.; Pypendop, B.H.; Siao, K.T.; Francey, T.; Dowers, K.; Cowgill, L.; Ilkiw, J.E. (2010). Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure. American journal of veterinary research, 71(5), pp. 501-7. Chicago, Ill.: American Veterinary Medical Association 10.2460/ajvr.71.5.501

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OBJECTIVE: To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure. ANIMALS: 23 dogs treated with a tibial plateau leveling osteotomy. PROCEDURES: 12 dogs were used as a control group. Cardiac output was measured in 5 dogs, and 6 dogs received carprofen for at least 14 days. Dogs received oxymorphone, atropine, propofol, and isoflurane for anesthesia (duration, 4 hours). Urine and blood samples were obtained for analysis every 30 minutes. Lactated Ringer's solution was administered at 10 mL/kg/h. Urine output was measured and glomerular filtration rate was estimated. Fluid retention was measured by use of body weight, fluid balance, and bioimpedance spectroscopy. RESULTS: No difference was found among control, cardiac output, or carprofen groups, so data were combined. Median urine output and glomerular filtration rate were 0.46 mL/kg/h and 1.84 mL/kg/min. Dogs retained a large amount of fluids during anesthesia, as indicated by increased body weight, positive fluid balance, increased total body water volume, and increased extracellular fluid volume. The PCV, total protein concentration, and esophageal temperature decreased in a linear manner. CONCLUSIONS AND CLINICAL RELEVANCE: Dogs anesthetized for a tibial plateau leveling osteotomy retained a large amount of fluids, had low urinary output, and had decreased PCV, total protein concentration, and esophageal temperature. Evaluation of urine output alone in anesthetized dogs may not be an adequate indicator of fluid balance.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Francey, Thierry

ISSN:

0002-9645

Publisher:

American Veterinary Medical Association

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.2460/ajvr.71.5.501

Web of Science ID:

000277053700001

URI:

https://boris.unibe.ch/id/eprint/14155 (FactScience: 221008)

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