Vitamin E: non-antioxidant roles.

Azzi, Angelo; Stocker, Achim (2000). Vitamin E: non-antioxidant roles. Progress in lipid research, 39(3), pp. 231-255. Elsevier 10.1016/s0163-7827(00)00006-0

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Vitamin E was originally considered a dietary factor of animal nutrition especially important for normal reproduction. The significance of vitamin E has been subsequently proven as a radical chain breaking antioxidant that can protect the integrity of tissues and play an important role in life processes. More recently alpha-tocopherol has been found to possess functions that are independent of its antioxidant/radical scavenging ability. Absorption in the body is alpha-tocopherol selective and other tocopherols are not absorbed or are absorbed to a lesser extent. Furthermore, pro-oxidant effects have been attributed to tocopherols as well as an anti-nitrating action. Non-antioxidant and non-pro-oxidant molecular mechanisms of tocopherols have been also described that are produced by alpha-tocopherol and not by beta-tocopherol. alpha-Tocopherol specific inhibitory effects have been seen on protein kinase C, on the growth of certain cells and on the transcription of some genes (CD36, and collagenase). Activation events have been seen on the protein phosphatase PP2A and on the expression of other genes (alpha-tropomyosin and Connective Tissue Growth Factor). Non-antioxidant molecular mechanisms have been also described for gamma-tocopherol, delta-tocopherol and tocotrienols.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Azzi, Angelo and Stocker, Achim

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0163-7827

Publisher:

Elsevier

Language:

English

Submitter:

Anja Ebeling

Date Deposited:

11 Mar 2020 16:38

Last Modified:

11 Mar 2020 16:47

Publisher DOI:

10.1016/s0163-7827(00)00006-0

PubMed ID:

10799717

BORIS DOI:

10.7892/boris.141815

URI:

https://boris.unibe.ch/id/eprint/141815

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