Paradisi, Francesca (17 February 2020). Versatility of transaminases in flow biocatalysis (Unpublished). In: Amine Biocatalysis 4.0.
The transaminase from H. elongata (HeAT), a halo-adapted bacterium, has shown excellent substrate scope and stability. Its immobilisation on solid supports has enabled even further stabilisation and recovery from the reaction mix. We have adapted transaminase mediated chemistry in continuous systems by trapping the catalyst in packed bed reactor. The move from batch to flow set up showed excellent improvements in reaction times and operational stability of the enzyme. Here the evolution and implementation of HeTA will be presented through several examples developed in our laboratory one the last three years
Item Type: |
Conference or Workshop Item (Speech) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Paradisi, Francesca |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
Language: |
English |
Submitter: |
Francesca Paradisi |
Date Deposited: |
06 Apr 2020 12:15 |
Last Modified: |
05 Dec 2022 15:37 |
Additional Information: |
oral presentation |
URI: |
https://boris.unibe.ch/id/eprint/141827 |
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