Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction

Raake, Philip W; Zhang, Xiaoying; Vinge, Leif E; Brinks, Henriette; Gao, Erhe; Jaleel, Naser; Li, Yingxin; Tang, Mingxin; Most, Patrick; Dorn, Gerald W; Houser, Steven R; Katus, Hugo A; Chen, Xiongwen; Koch, Walter J (2012). Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation, 125(17), pp. 2108-18. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.111.044255

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G-protein-coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. G-protein-coupled receptor kinase 2 ablation impedes heart failure development, but elucidation of the cellular mechanisms has not been achieved, and such elucidation is the aim of this study.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Most, Henriette

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0009-7322

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

17 Dec 2014 07:45

Publisher DOI:

10.1161/CIRCULATIONAHA.111.044255

PubMed ID:

22496128

Web of Science ID:

000306959200020

URI:

https://boris.unibe.ch/id/eprint/14195 (FactScience: 221050)

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