[Synthetic chromosomes: rewriting the code of life].

Baby, Vincent; Labroussaa, Fabien; Lartigue, Carole; Rodrigue, Sébastien (2019). [Synthetic chromosomes: rewriting the code of life]. médecine/sciences, 35(10), pp. 753-760. EDP Sciences 10.1051/medsci/2019153

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The past decade has seen vast improvements in DNA synthesis and assembly methods. The creation of synthetic DNA molecules is becoming easier and more affordable, such that entire chromosomes can now be synthesized. These advances mark the beginning of synthetic genomics, a new discipline interested in the construction of complete genomes tailored for the study and application of biological systems. From viral genome synthesis to the reconstruction of the yeast 16 chromosomes, we discuss the main discoveries, the regulations and ethical considerations along with the potential of this emerging discipline for the future.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Labroussaa, Fabien

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

0767-0974

Publisher:

EDP Sciences

Language:

French

Submitter:

Achim Braun Parham

Date Deposited:

02 Apr 2020 10:08

Last Modified:

02 Apr 2020 10:08

Publisher DOI:

10.1051/medsci/2019153

PubMed ID:

31625897

BORIS DOI:

10.7892/boris.142101

URI:

https://boris.unibe.ch/id/eprint/142101

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