In vivo role of capsular polysaccharide in Mycoplasma mycoides.

Jores, Jörg; Schieck, Elise; Liljander, Anne; Sacchini, Flavio; Posthaus, Horst; Lartigue, Carole; Blanchard, Alain; Labroussaa, Fabien; Vashee, Sanjay (2019). In vivo role of capsular polysaccharide in Mycoplasma mycoides. The journal of infectious diseases, 219(10), pp. 1559-1563. Oxford University Press 10.1093/infdis/jiy713

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Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, 5 of 8 goats infected with the parental strain reached end-point criteria after infection. These findings confirm that galactofuranose is a virulence factor in M. mycoides.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology

UniBE Contributor:

Jores, Jörg; Posthaus, Horst and Labroussaa, Fabien

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

1537-6613

Publisher:

Oxford University Press

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

02 Apr 2020 11:22

Last Modified:

02 Apr 2020 11:22

Publisher DOI:

10.1093/infdis/jiy713

PubMed ID:

30541131

Uncontrolled Keywords:

M. mycoides subsp. capri Mycoplasma mycoides CPS carbohydrate galactofuranose glycan vaccine virulence factor

BORIS DOI:

10.7892/boris.142105

URI:

https://boris.unibe.ch/id/eprint/142105

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