The cellular basis of GABAB-mediated interhemispheric inhibition

Palmer, L M; Schulz, J M; Murphy, S C; Ledergeber, D; Murayama, M; Larkum, M E (2012). The cellular basis of GABAB-mediated interhemispheric inhibition. Science, 335(6071), pp. 989-993. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1217276

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nterhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABAB) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Palmer, Lucy

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

05 Dec 2022 14:11

Publisher DOI:

10.1126/science.1217276

Web of Science ID:

000300931800052

BORIS DOI:

10.7892/boris.14225

URI:

https://boris.unibe.ch/id/eprint/14225 (FactScience: 221090)

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