TRP Channels in Digestive Tract Cancers.

Stoklosa, Paulina; Borgström, Anna; Kappel, Sven; Peinelt, Christine (2020). TRP Channels in Digestive Tract Cancers. International journal of molecular sciences, 21(5) Molecular Diversity Preservation International MDPI 10.3390/ijms21051877

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Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and the inability to induce apoptosis. Therefore, TRP channels could serve as potential diagnostic biomarkers. Moreover, TRP channels are mostly expressed on the cell surface and ion channel targeting drugs do not need to enter the cell, making them attractive candidate drug targets. In this review, we summarize the current knowledge about TRP channels in connection to digestive tract cancers (oral cancer, esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer) and give an outlook on the potential of TRP channels as cancer biomarkers or therapeutic targets.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > NCCR TransCure
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Stoklosa, Paulina Agnieszka; Borgström, Anna; Kappel, Sven and Peinelt, Christine

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Funders:

[65] NCCR TransCure

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

21 Apr 2020 15:19

Last Modified:

21 Apr 2020 15:19

Publisher DOI:

10.3390/ijms21051877

PubMed ID:

32182937

Uncontrolled Keywords:

TRP channel apoptosis cancer cancer hallmarks cell cycle gastrointestinal tract invasion migration

BORIS DOI:

10.7892/boris.142627

URI:

https://boris.unibe.ch/id/eprint/142627

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