Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review

Mejri, N.; Hemphill, A.; Gottstein, B. (2010). Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review. Parasitology, 137(3), pp. 557-68. London: Cambridge University Press 10.1017/S0031182009991533

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As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cells of both the innate and adaptive arms of the immune response, E. multilocularis can orchestrate a range of outcomes that are beneficial not only to the parasite, in terms of facilitating its intrahepatic proliferation and maturation, and thus life cycle over all, but also to its intermediate host, in limiting pathology. The present review deals with the role of metacestode surface molecules as well as excretory/secretory (E/S) metabolic products of the parasite in the modulation of the host responses such as to optimize its own survival.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Hemphill, Andrew and Gottstein, Bruno

ISSN:

0031-1820

Publisher:

Cambridge University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:36

Last Modified:

23 Oct 2019 23:55

Publisher DOI:

10.1017/S0031182009991533

PubMed ID:

19961650

Web of Science ID:

000276440600017

BORIS DOI:

10.7892/boris.14297

URI:

https://boris.unibe.ch/id/eprint/14297 (FactScience: 221192)

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