Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay

Vuitton, Dominique Angèle; Gottstein, Bruno (2010). Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay. Journal of biomedicine and biotechnology, 2010, p. 923193. Akron, Ohio: Hindawi Pub. Corp. 10.1155/2010/923193

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Host-parasite interactions in the E. multilocularis-intermediate host model depend on a subtle balance between cellular immunity, which is responsible for host's resistance towards the metacestode, the larval stage of the parasite, and tolerance induction and maintenance. The pathological features of alveolar echinococcosis. the disease caused by E. multilocularis, are related both to parasitic growth and to host's immune response, leading to fibrosis and necrosis, The disease spectrum is clearly dependent on the genetic background of the host as well as on acquired disturbances of Th1-related immunity. The laminated layer of the metacestode, and especially its carbohydrate components, plays a major role in tolerance induction. Th2-type and anti-inflammatory cytokines, IL-10 and TGF-beta, as well as nitric oxide, are involved in the maintenance of tolerance and partial inhibition of cytotoxic mechanisms. Results of studies in the experimental mouse model and in patients suggest that immune modulation with cytokines, such as interferon-alpha, or with specific antigens could be used in the future to treat patients with alveolar echinococcosis and/or to prevent this very severe parasitic disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Gottstein, Bruno

ISSN:

1110-7243

Publisher:

Hindawi Pub. Corp.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:36

Last Modified:

22 Jul 2018 01:37

Publisher DOI:

10.1155/2010/923193

PubMed ID:

20339517

Web of Science ID:

000276244200001

BORIS DOI:

10.7892/boris.14305

URI:

https://boris.unibe.ch/id/eprint/14305 (FactScience: 221200)

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