DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation.

Zindel, Joel; Kubes, Paul (2020). DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. Annual Review of Pathology: Mechanisms of Disease, 15, pp. 493-518. 10.1146/annurev-pathmechdis-012419-032847

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Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic breakthroughs. However, many inflammatory pathologies remain without specific therapy. This review discusses leukocytes in the context of sterile inflammation, a process caused by sterile (non-microbial) molecules, comprising damage-associated molecular patterns (DAMPs). DAMPs bind specific receptors to activate inflammation and start a highly optimized sequence of immune cell recruitment of neutrophils and monocytes to initiate effective tissue repair. When DAMPs are cleared, the recruited leukocytes change from a proinflammatory to a reparative program, a switch that is locally supervised by invariant natural killer T cells. In addition, neutrophils exit the inflammatory site and reverse transmigrate back to the bloodstream. Inflammation persists when the program switch or reverse transmigration fails, or when the coordinated leukocyte effort cannot clear the immunostimulatory molecules. The latter causes inappropriate leukocyte activation, a driver of many pathologies associated with poor lifestyle choices. We discuss lifestyle-associated inflammatory diseases and their corresponding immunostimulatory lifestyle-associated molecular patterns (LAMPs) and distinguish them from DAMPs.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Zindel, Joel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1553-4014

Funders:

Organisations 0 not found.

Language:

English

Submitter:

Dr. med. Joel Zindel

Date Deposited:

28 Apr 2020 11:59

Last Modified:

04 Sep 2020 09:53

Publisher DOI:

10.1146/annurev-pathmechdis-012419-032847

PubMed ID:

31675482

BORIS DOI:

10.7892/boris.143342

URI:

https://boris.unibe.ch/id/eprint/143342

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