A biased adenosine A1R agonist elicits analgesia without cardiorespiratory depression

Wall, Mark J.; Hill, Emily; Huckstepp, Robert; Barkan, Kerry; Deganutti, Giuseppe; Leuenberger, Michele; Preti, Barbara; Winfield, Ian; Wei, Haifeng; Imlach, Wendy; Dean, Eve; Hume, Cherise; Hayward, Stephanie; Oliver, Jess; Zhao, Fei-Yue; Spanswick, David; Reynolds, Christopher A.; Lochner, Martin; Ladds, Graham and Frenguelli, Bruno G. (4 August 2020). A biased adenosine A1R agonist elicits analgesia without cardiorespiratory depression bioRxiv 10.1101/2020.04.04.023945

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Short summary: We describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-reaching concept of biased agonism.

Item Type:

Working Paper

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Leuenberger, Michele; Preti, Barbara and Lochner, Martin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
500 Science > 540 Chemistry

Publisher:

bioRxiv

Funders:

[4] Swiss National Science Foundation
[UNSPECIFIED] BBSRC
[UNSPECIFIED] Leverhulme Trust
[UNSPECIFIED] MRC

Language:

English

Submitter:

Martin Lochner

Date Deposited:

04 May 2020 16:49

Last Modified:

27 Oct 2020 08:28

Publisher DOI:

10.1101/2020.04.04.023945

BORIS DOI:

10.7892/boris.143509

URI:

https://boris.unibe.ch/id/eprint/143509

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