Anti-apolipoprotein A-1 autoantibodies correlate with disease activity in systemic lupus erythematosus.

Nigolian, Haïg; Ribi, Camillo; Courvoisier, Delphine S; Pagano, Sabrina; Alvarez, Montserrat; Trendelenburg, Marten; Huynh-Do, Uyen; Vuilleumier, Nicolas; Dayer, Jean-Michel; Chizzolini, Carlo; Roux-Lombard, Pascale (2020). Anti-apolipoprotein A-1 autoantibodies correlate with disease activity in systemic lupus erythematosus. Rheumatology, 59(3), pp. 534-544. Oxford University Press 10.1093/rheumatology/kez306

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OBJECTIVES

Apolipoprotein A-1 (ApoA-1) is a protein fraction of the high-density lipoproteins with anti-inflammatory and antioxidant properties that play a major role in reverse cholesterol transport. The presence of anti-ApoA-1 IgG has been reported in SLE to be variably associated with disease activity or cardiovascular events (CVEs). We assessed the clinical performance of anti-ApoA-1 IgG and of antibodies directed against its immunodominant F3L1 peptide (F3L1 IgG) in a well-characterized Swiss SLE cohort study.

METHODS

A total of 354 biological samples and interviews from 176 individuals were studied. SLEDAI, clinical characteristics, anamnestic CVEs and therapy details were recorded. Sera were tested for the presence of anti-ApoA-1 IgG, anti-F3L1 IgG, anti-dsDNA IgG and aPL.

RESULTS

Anti-ApoA-1 and anti-F3L1 IgG positivity was associated with higher SLEDAI, mostly due to concomitant positivity of dsDNA IgG and low complement. Variations in time of anti-ApoA-1 IgG correlated positively with variations of anti-dsDNA IgG and inversely to variations of C3 levels. No cross-reactivity was found between anti-ApoA-1 and anti-dsDNA IgG. Positivity for anti-Apo-A1 IgG was more frequent in individuals receiving 10 mg/day or more of prednisone. We did not find any significant association between anti-ApoA-1 IgG positivity and CVEs.

CONCLUSION

Anti-ApoA-1 and anti-F3L1 IgG in SLE correlate strongly with laboratory markers of activity, particularly with the presence and titre of dsDNA IgG. These results confirm and extend previous findings and support the use of anti-ApoA1 IgG in the clinical setting. Their role in CVEs deserves further investigation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Huynh-Do, Uyen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1462-0324

Publisher:

Oxford University Press

Language:

English

Submitter:

Uyen Huynh-Do

Date Deposited:

05 May 2020 17:02

Last Modified:

05 May 2020 17:09

Publisher DOI:

10.1093/rheumatology/kez306

PubMed ID:

31377780

Uncontrolled Keywords:

SLEDAI anti-F3L1 antibody anti-apolipoprotein-A1 antibody anti-dsDNA antibody anti-phospholipids antibody biomarker cardiovascular events systemic lupus erythematosus

BORIS DOI:

10.7892/boris.143653

URI:

https://boris.unibe.ch/id/eprint/143653

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