Environmental concentration of methamphetamine induces pathological changes in brown trout (Salmo trutta fario)

Sancho Santos, Maria Eugenia; Grabicova, Katerina; Steinbach, Christoph; Schmidt-Posthaus, Heike; Salkova, Eva; Kolarova, Jitka; Stanova, Andrea Vojs; Grabic, Roman; Randak, Tomas (2020). Environmental concentration of methamphetamine induces pathological changes in brown trout (Salmo trutta fario). Chemosphere, 254, p. 126882. Elsevier Science 10.1016/j.chemosphere.2020.126882

[img] Text
Sancho Santos_2020_metamphethamine.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (6MB) | Request a copy

Methamphetamine, mainly consumed as an illicit drug, is a potent addictive psychostimulant that has been detected in surface water at concentrations ranging from nanograms to micrograms per litre, especially in Middle and East Europe. The aim of this study was to expose brown trout (Salmo trutta fario) to environmental (1 μg L−1) and higher (50 μg L−1) concentrations of methamphetamine for 35 days with a four-day depuration phase to assess the possible negative effects on fish health. Degenerative liver and heart alterations, similar to those described in mammals, were observed at both concentrations, although at different intensities. Apoptotic changes in hepatocytes, revealed by activated caspase-3, were found in exposed fish. The parent compound and a metabolite (amphetamine) were detected in fish tissues in both concentration groups, in the order of kidney > liver > brain > muscle > plasma. Bioconcentration factors ranged from 0.13 to 80. A therapeutic plasma concentration was reached for both compounds in the high-concentration treatment. This study indicates that chronic environmental concentrations of methamphetamine can lead to health issues in aquatic organisms.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Schmidt-Posthaus, Heike

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0045-6535

Publisher:

Elsevier Science

Language:

English

Submitter:

Heike Schmidt Posthaus

Date Deposited:

13 May 2020 17:24

Last Modified:

14 May 2020 01:33

Publisher DOI:

10.1016/j.chemosphere.2020.126882

BORIS DOI:

10.7892/boris.143892

URI:

https://boris.unibe.ch/id/eprint/143892

Actions (login required)

Edit item Edit item
Provide Feedback