Slow release antibiotics for treatment of septic arthritis in large animals

Haerdi-Landerer, M.C.; Habermacher, J.; Wenger, B.; Suter, M.M.; Steiner, Adrian (2010). Slow release antibiotics for treatment of septic arthritis in large animals. Veterinary journal, 184(1), pp. 14-20. Amsterdam: Elsevier 10.1016/j.tvjl.2009.02.013

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The search for an effective treatment for septic arthritis is ongoing. Current therapies are expensive since they require repeated joint lavage and long term antibiotic treatment. Local application of antimicrobial drugs is advantageous because high concentrations can be attained at the infection site, although repeated injections increase the risk of superinfection of the joint. Thus, slow release formulations, which have the advantage of local treatment yet single application of the drug, are appealing. Antibiotics used in slow release formulations are selected for tissue compatibility, an appropriate antibacterial spectrum, and stability both during the mixing procedure and within the carrier during the release period. Ideally the carriers should be bioresorbable. Promising reports on the clinical use of poly(methyl methacrylate) (PMMA) mixed with several different antibiotics, and of collagen sponges impregnated with gentamicin, should encourage the search for formulations optimally adapted to veterinary medical requirements.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Clinic for Ruminants
UniBE Contributor:	Steiner, Adrian
Subjects:	600 Technology > 630 Agriculture
ISSN:	1090-0233
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:36
Last Modified:	05 Dec 2022 14:11
Publisher DOI:	10.1016/j.tvjl.2009.02.013
Web of Science ID:	000276140800006
URI:	https://boris.unibe.ch/id/eprint/14400 (FactScience: 221375)