Emerging approaches for restoration of hearing and vision

Kleinlogel, Sonja; Vogl, Christian; Jeschke, Marcus; Neef, Jakob; Moser, Tobias (2020). Emerging approaches for restoration of hearing and vision. Physiological reviews, 100(4), pp. 1467-1525. American Physiological Society 10.1152/physrev.00035.2019

[img] Text
Kleinlogel2020Emergingap.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (5MB) | Request a copy

Impairments of vision and hearing are highly prevalent conditions limiting the quality of life and presenting a major socioeconomic burden. For long, retinal and cochlear disorders have remained intractable for causal therapies, with sensory rehabilitation limited to glasses, hearing aids, and electrical cochlear or retinal implants. Recently, the application of gene therapy and optogenetics to eye and ear has generated hope for a fundamental improvement of vision and hearing restoration. To date, one gene therapy for the restoration of vision has been approved and undergoing clinical trials will broaden its application including gene replacement, genome editing, and regenerative approaches. Moreover, optogenetics, i.e. controlling the activity of cells by light, offers a more general alternative strategy. Over little more than a decade, optogenetic approaches have been developed and applied to better understand the function of biological systems, while protein engineers have identified and designed new opsin variants with desired physiological features. Considering potential clinical applications of optogenetics, the spotlight is on the sensory systems. Multiple efforts have been undertaken to restore lost or hampered function in eye and ear. Optogenetic stimulation promises to overcome fundamental shortcomings of electrical stimulation, namely poor spatial resolution and cellular specificity, and accordingly to deliver more detailed sensory information. This review aims at providing a comprehensive reference on current gene therapeutic and optogenetic research relevant to the restoration of hearing and vision. We will introduce gene-therapeutic approaches and discuss the biotechnological and optoelectronic aspects of optogenetic hearing and vision restoration

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Kleinlogel, Sonja


600 Technology > 610 Medicine & health




American Physiological Society


Stefan von Känel-Zimmermann

Date Deposited:

19 May 2020 15:36

Last Modified:

08 Jul 2020 01:32

Publisher DOI:


PubMed ID:






Actions (login required)

Edit item Edit item
Provide Feedback