Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies.

Alsaaod, Maher; Fadul, Mahmoud; Deiss, Ramona; Bucher, Esther; Rehage, Juergen; Guccione, Jacopo; Steiner, Adrian (2019). Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies. PLoS ONE, 14(11), p. 1. Public Library of Science 10.1371/journal.pone.0225565

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[This corrects the article DOI: 10.1371/journal.pone.0218546.]. Abstract In veterinary practice pain alleviation plays a part in managing lameness. The aim of this randomized and placebo-controlled clinical study was to evaluate the effect of a single administration of ketoprofen on locomotion characteristics and weight distribution in cattle with foot (located up to and including the fetlock; n = 31) and (proximal to the fetlock; n = 10) pathologies. Cattle were randomly allocated to either the ketoprofen (group K; intravenous 3 mg/kg of body weight; n = 21) or an equivalent volume of isotonic sterile saline solution (group P; n = 20). Two accelerometers (400 Hz; kinematic outcome = stance phase duration; kinetic outcome = foot load and toe-off), a 4-scale weighing platform (weight distribution and SD of the weight) and a subjective locomotion score were measured before (baseline) and after 1 h and 18 h of treatment. All variables were expressed as differences across contralateral limbs, and the measurements at 1 h and 18 h were compared to the baseline. A repeated measures ANOVA was used to determine the differences between groups K and P. A logistic regression model with a binary outcome (0 = no improvement and 1 = improvement of the differences across the contralateral limbs over time) was calculated. Mean (± SD) of locomotion scores at baseline were not significantly different (P = 0.102) in group K (3.10 ± 0.80) as compared to group P (3.48 ± 0.64). Cattle of group K showed significantly lower differences across contralateral limbs at 1 h as compared to group P for the relative stance phase and the weight distribution. Only the treatment (P versus K) remained a significant factor in the model for relative stance phase (odds ratio (OR) = 6.5; 95% CI = 1.38–30.68) and weight distribution (OR = 6.36; 95% CI = 1.30–31.07). The effects of ketoprofen were evident in improving the differences across contralateral limbs—both for stance phase during walking and weight bearing during standing—after 1 h but not after 18 h of administration.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Clinic for Ruminants
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Alsaaod, Maher; Fadul, Mahmoud Mohamed Osman; Deiss, Ramona; Bucher, Esther and Steiner, Adrian

Subjects:

600 Technology > 630 Agriculture
500 Science
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Nathalie Viviane Zollinger

Date Deposited:

09 Jun 2020 10:42

Last Modified:

09 Jun 2020 10:51

Publisher DOI:

10.1371/journal.pone.0225565

PubMed ID:

31725807

BORIS DOI:

10.7892/boris.144196

URI:

https://boris.unibe.ch/id/eprint/144196

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