Agricultural crop density in the municipalities of France and incidence of childhood leukemia: An ecological study.

Coste, Astrid; Goujon, Stéphanie; Faure, Laure; Hémon, Denis; Clavel, Jacqueline (2020). Agricultural crop density in the municipalities of France and incidence of childhood leukemia: An ecological study. Environmental research, 187, p. 109517. Elsevier 10.1016/j.envres.2020.109517

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BACKGROUND Pesticide exposure is suspected to play a role in the etiology of childhood leukemia (AL). Various sources of exposure have been explored, but few studies have investigated the risk of childhood AL in relation to residential exposure to agricultural pesticides. Since around 50% of France is agricultural land, with marked pesticide use, France is a suitable location to investigate for an association. We aimed to analyze the association between the agricultural crop density in the municipalities of France and the incidence of childhood AL between 1990 and 2014. METHODS 11,487 cases of AL diagnosed in children aged 0-14 years were registered by the French National Registry of Childhood Hematological Malignancies over 1990-2014. National agricultural census data for 1990, 2000 and 2010 were used to estimate the densities of the most common crops in France. The incidence of AL was estimated in the 35,512 municipalities, by age and gender, and 3 observation periods, and expressed as the standardized incidence ratio (SIR). RESULTS We observed a moderate log-linear association between viticulture density and the incidence of AL, with a 3% increase in SIR for a 10% increase in viticulture density (SIRR = 1.03; 95%CI [1.00-1.06]). The association remained for lymphoblastic AL but not for myeloid AL. The association was stable after stratification by geographic area, age and period, and after adjustment on UV radiation and a French deprivation index. No consistent association was observed for other crop types. DISCUSSION This nationwide study shows a moderate increase in incidence of childhood AL in municipalities where viticulture is common. Future individual studies are needed to know whether this observation is confirmed and related to particular use of pesticides.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Coste, Astrid

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0013-9351

Publisher:

Elsevier

Language:

English

Submitter:

Beatrice Minder Wyssmann

Date Deposited:

22 May 2020 09:53

Last Modified:

21 Jun 2020 01:34

Publisher DOI:

10.1016/j.envres.2020.109517

PubMed ID:

32438101

Uncontrolled Keywords:

Agriculture Childhood leukemia Ecological study Pesticides Record-based study

BORIS DOI:

10.7892/boris.144241

URI:

https://boris.unibe.ch/id/eprint/144241

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