TriB-RT: simultaneous optimization of photon, electron and proton beams.

Küng, Reto; Mueller, Silvan; Löbner, Hannes Anton; Frei, Daniel; Volken, Werner; Aebersold, Daniel M.; Stampanoni, Marco F M; Fix, Michael K.; Manser, Peter (2020). TriB-RT: simultaneous optimization of photon, electron and proton beams. (In Press). Physics in medicine and biology Institute of Physics Publishing IOP 10.1088/1361-6560/ab936f

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PURPOSE To develop a novel treatment planning process (TPP) with simultaneous optimization of modulated photon, electron and proton beams for improved treatment plan quality in radiotherapy. METHODS A framework for fluence map optimization of Monte Carlo (MC) calculated beamlet dose distributions is developed to generate treatment plans consisting of photon, electron and spot scanning proton fields. Initially, in-house intensity modulated proton therapy (IMPT) plans are compared to proton plans created by a commercial treatment planning system (TPS). A Triple Beam radiotherapy (TriB-RT) plan is generated for an exemplary academic case and the dose contributions of the three particle types are investigated. To investigate the dosimetric potential, a TriB-RT plan is compared to an in-house IMPT plan for two clinically motivated cases. Benefits of TriB-RT for a fixed proton beam line with a single proton field are investigated. RESULTS In-house optimized IMPT are of at least equal or better quality than TPS generated proton plans and MC-based optimization shows dosimetric advantages for inhomogeneous situations. Concerning TriB-RT, for the academic case, the resulting plan shows substantial contribution of all particle types. For the clinically motivated, improved sparing of organs at risk close to the target volume is achieved compared to IMPT (e.g. myelon and brainstem Dmax -37%) at cost of an increased low dose bath (healthy tissue V10 +22\%). In the scenario of a fixed proton beam line, TriB-RT plans are able to compensate the loss in degrees of freedom to substantially improve plan quality compared to a single field proton plan. CONCLUSION A novel TPP which simultaneously optimizes photon, electron and proton beams was successfully developed. TriB-RT shows the potential for improved treatment quality and is especially promising for cost-effective single-room proton solutions with a fixed beamline in combination with a conventional linac delivering photon and electron fields.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics

UniBE Contributor:

Küng, Reto; Müller, Silvan Andreas; Löbner, Hannes Anton; Frei, Daniel; Volken, Werner; Aebersold, Daniel; Fix, Michael and Manser, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0031-9155

Publisher:

Institute of Physics Publishing IOP

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

08 Jun 2020 14:50

Last Modified:

08 Jun 2020 14:59

Publisher DOI:

10.1088/1361-6560/ab936f

PubMed ID:

32413883

Uncontrolled Keywords:

Monte Carlo TriB-RT Triple Beam radiotherapy simultaneous optimization

BORIS DOI:

10.7892/boris.144291

URI:

https://boris.unibe.ch/id/eprint/144291

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