Genomic Subtyping in Bladder Cancer.

Jalanko, Tuomas; de Jong, Joep J; Gibb, Ewan A; Seiler, Roland; Black, Peter C (2020). Genomic Subtyping in Bladder Cancer. Current urology reports, 21(2), p. 9. Springer 10.1007/s11934-020-0960-y

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PURPOSE OF REVIEW

Molecular characterization of cancer allows us to understand oncogenesis and clinical prognosis as well as facilitates development of biomarkers and treatment. Our aim was to review the current literature on genomic characterization of bladder cancer, and how far we are in implementing genomics into clinical practice.

RECENT FINDINGS

Bladder cancers are molecularly diverse tumors with a high mutational rate. On molecular level, bladder cancer can be categorized into at least six subtypes called luminal-papillary, luminal-unstable, luminal non-specified, basal-squamous, neuroendocrine-like, and stroma-rich. These subtypes have characteristic genomic and transcriptomic profiles and appear to have different prognoses. Several molecular subtypes have been identified in bladder cancer. Prospective trials are underway to validate the applicability of genomic subtypes for clinical decision making. Further integrative analyses of genomic alterations, gene expression, epigenetics, and proteomics need to be performed before genomic subtyping can be attained in clinical practice.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Seiler-Blarer, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1534-6285

Publisher:

Springer

Language:

English

Submitter:

Jeannine Wiemann

Date Deposited:

09 Jun 2020 07:38

Last Modified:

28 Nov 2020 02:30

Publisher DOI:

10.1007/s11934-020-0960-y

PubMed ID:

32166460

Uncontrolled Keywords:

Bladder cancer Genomic analysis Immunotherapy Molecular subtyping Mutations Neoadjuvant chemotherapy

BORIS DOI:

10.7892/boris.144423

URI:

https://boris.unibe.ch/id/eprint/144423

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