Reference values and clinical predictors of bone strength for HR-pQCT-based distal radius and tibia strength assessments in women and men.

Stuck, A. K.; Schenk, D.; Zysset, P.; Bütikofer, L.; Mathis, A.; Lippuner, K. (2020). Reference values and clinical predictors of bone strength for HR-pQCT-based distal radius and tibia strength assessments in women and men. Osteoporosis international, 31(10), pp. 1913-1923. Springer-Verlag 10.1007/s00198-020-05405-0

[img] Text
Stuck OsteoporosInt 2020.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy
[img] Text
Stuck OsteoporosInt 2020_AAM.pdf - Accepted Version
Restricted to registered users only until 26 May 2021.
Available under License Publisher holds Copyright.

Download (521kB) | Request a copy
[img] Text
Stuck OsteoporosInt 2020_supplmat.pdf - Supplemental Material
Restricted to registered users only until 26 May 2021.
Available under License Publisher holds Copyright.

Download (660kB) | Request a copy

Reference values for radius and tibia strength using multiple-stack high-resolution peripheral quantitative computed tomography (HR-pQCT) with homogenized finite element analysis are presented in order to derive critical values improving risk prediction models of osteoporosis. Gender and femoral neck areal bone mineral density (aBMD) were independent predictors of bone strength.

INTRODUCTION

The purpose was to obtain reference values for radius and tibia bone strength computed by using the homogenized finite element analysis (hFE) using multiple stacks with a HR-pQCT.

METHODS

Male and female healthy participants aged 20-39 years were recruited at the University Hospital of Bern. They underwent interview and clinical examination including hand grip, gait speed and DXA of the hip. The nondominant forearm and tibia were scanned with a double and a triple-stack protocol, respectively, using HR-pQCT (XCT II, SCANCO Medical AG). Bone strength was estimated by using the hFE analysis, and reference values were calculated using quantile regression. Multivariable analyses were performed to identify clinical predictors of bone strength.

RESULTS

Overall, 46 women and 41 men were recruited with mean ages of 25.1 (sd 5.0) and 26.2 (sd 5.2) years. Sex-specific reference values for bone strength were established. Men had significantly higher strength for radius (mean (sd) 6640 (1800) N vs. 4110 (1200) N; p < 0.001) and tibia (18,200 (4220) N vs. 11,970 (3150) N; p < 0.001) than women. In the two multivariable regression models with and without total hip aBMD, the addition of neck hip aBMD significantly improved the model (p < 0.001). No clinical predictors of bone strength other than gender and aBMD were identified.

CONCLUSION

Reference values for radius and tibia strength using multiple HR-pQCT stacks with hFE analysis are presented and provide the basis to help refining accurate risk prediction models. Femoral neck aBMD and gender were significant predictors of bone strength.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Musculoskeletal Biomechanics
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Osteoporosis
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic > Geriatric Clinic Inselspital
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Stuck, Andreas; Schenk, Denis Elia; Zysset, Philippe; Bütikofer, Lukas; Mathis, Andrea Maria and Lippuner, Kurt

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0937-941X

Publisher:

Springer-Verlag

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

05 Jun 2020 12:01

Last Modified:

25 Nov 2020 18:04

Publisher DOI:

10.1007/s00198-020-05405-0

PubMed ID:

32451557

Uncontrolled Keywords:

Bone strength Clinical predictors Failure load Finite element analysis HR-pQCT Multiple stacks Reference values

BORIS DOI:

10.7892/boris.144454

URI:

https://boris.unibe.ch/id/eprint/144454

Actions (login required)

Edit item Edit item
Provide Feedback