Recommendations on the use of anticoagulants for the treatment of patients with heparin-induced thrombocytopenia in Switzerland.

Alberio, Lorenzo A.; Angelillo-Scherrer, Anne; Asmis, Lars M.; Casini, Alessandro; Fontana, Pierre; Graf, Lukas; Hegemann, Inga; Kremer Hovinga, Johanna A.; Korte, Wolfgang; Lecompte, Thomas; Martinez, Martina; Nagler, Michael; Studt, Jan-Dirk; Tsakiris, Dimitrios A.; Wuillemin, Walter A. (2020). Recommendations on the use of anticoagulants for the treatment of patients with heparin-induced thrombocytopenia in Switzerland. Swiss medical weekly, 150(w20210), w20210. EMH Media 10.4414/smw.2020.20210

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Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug effect that occurs in 0.1–5% of heparin treated patients. Management of acute HIT currently involves (1) cessation of heparin exposure, and (2) inhibition of coagulation with an anticoagulant other than heparin. Several anticoagulants can be considered for the treatment of HIT. Anticoagulant monitoring, management of drug-induced adverse events including bleeding, and therapeutic dosing schedules in selected clinical settings represent challenges to the clinician treating HIT patients. Moreover, the fact that not all registered anticoagulants are approved for HIT in Switzerland further complicates the management of HIT. The present recommendations on the anticoagulant treatment of HIT in Switzerland have been elaborated by a panel of Swiss experts belonging to the Working Party Hemostasis (WPH) of the Swiss Society of Hematology (SGH-SSH). They are intended to support clinicians in their decision making when treating HIT patients.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Angelillo, Anne; Kremer Hovinga, Johanna Anna and Nagler, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-3997

Publisher:

EMH Media

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

15 Jun 2020 09:46

Last Modified:

21 Jun 2020 02:41

Publisher DOI:

10.4414/smw.2020.20210

PubMed ID:

32329806

BORIS DOI:

10.7892/boris.144476

URI:

https://boris.unibe.ch/id/eprint/144476

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