Current concepts and future directions for hemato-oncologic diagnostics.

Flach, Johanna; Shumilov, Evgenii; Joncourt, Raphael; Porret, Naomi; Novak, Urban; Pabst, Thomas; Bacher, Ulrike (2020). Current concepts and future directions for hemato-oncologic diagnostics. Critical reviews in oncology, hematology, 151, p. 102977. Elsevier 10.1016/j.critrevonc.2020.102977

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At present, hemato-oncologic diagnostics is facing dynamic changes. This applies to the exploration and introduction of novel technologies such as next-generation sequencing or digital droplet PCR for myeloid and lymphatic malignancies in laboratory routine, or liquid biopsy for patients with lymphoid malignancies. Targeted therapies such as FLT3 or IDH1/IDH2 inhibitors for acute myeloid leukemia are entering clinical practice. Thus, the demand for hematologic precision diagnostics both at initial diagnosis and during the course of the disease are equally increasing, and a short turn-around time becomes crucial. NGS expands the armamentarium for minimal residual disease diagnostics, but novel questions arise relating to sensitivity, the appropriate time points of this analysis, or the thresholds triggering therapeutic interventions. In this review article, we summarize some of the most relevant current changes and subsequent challenges for diagnostics in various myeloid and lymphatic malignancies. Future directions of hemato-oncologic diagnostics in the next 5-10 years are highlighted.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Joncourt, Raphael; Porret, Naomi; Novak, Urban; Pabst Müller, Thomas Niklaus and Bacher, Vera Ulrike

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1040-8428

Publisher:

Elsevier

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

15 Jun 2020 10:07

Last Modified:

15 Jun 2020 10:15

Publisher DOI:

10.1016/j.critrevonc.2020.102977

PubMed ID:

32446181

Uncontrolled Keywords:

Acute lymphatic leukemia (ALL) Acute myeloid leukemia (AML) Hemato-oncologic diagnostics Liquid biopsy Lymphomas Multiple myeloma Next-generation sequencing (NGS) Novel technologies

BORIS DOI:

10.7892/boris.144484

URI:

https://boris.unibe.ch/id/eprint/144484

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