Two-year outcome comparison of decompression in 14 lipomatosis cases with 169 degenerative lumbar spinal stenosis cases: a Swiss prospective multicenter cohort study.

Ulrich, Nils H; Gravestock, Isaac; Winklhofer, Sebastian; Peyneshki, Iliya; Wertli, Maria M.; Pichierri, Giuseppe; Fekete, Tamás F; Porchet, François; Farshad, Mazda; Steurer, Johann; Burgstaller, Jakob M (2020). Two-year outcome comparison of decompression in 14 lipomatosis cases with 169 degenerative lumbar spinal stenosis cases: a Swiss prospective multicenter cohort study. European spine journal, 29(9), pp. 2243-2253. Springer 10.1007/s00586-020-06449-w

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PURPOSE

Spinal epidural lipomatosis (SEL) is defined as an abnormal and extensive accumulation of unencapsulated adipose tissue within the spinal epidural space. To date, there is a lack of high-level evidence studies reporting the outcome of surgical treatment of symptomatic SEL in patients with lumbar spinal stenosis (LSS). The aim was to compare clinical outcomes in patients with symptomatic LSS with and without SEL who underwent decompression surgery alone at the 12- and 24-month follow-up.

METHODS

One hundred and eighty-three patients met the inclusion criteria, of which 14 had mainly SEL on at least one level operated in addition to possible degenerative changes on other levels and 169 degenerative LSS only. The main outcomes were pain (Spinal Stenosis Measure (SSM) symptoms), disability (SSM function), and quality of life [EQ-5D-3L summary index (SI)] at 24-month follow-up, and minimal clinically important difference (MCID) in SSM symptoms, SSM function, and EQ-5D-3L SI.

RESULTS

The multiple regression linear models showed that SEL was associated with worse SSM symptoms (p = 0.045) and EQ-5D-3L SI scores (p = 0.026) at 24-month follow-up, but not with worse SSM function scores. Further, depression (in all models) was negatively associated with better clinical outcomes at 24-month follow-up. In the outcomes SSM symptoms and EQ-5D-3L SI, distinctly more patients in the classical LSS group reached MCID than in the SEL group (71.3% and 62.3% vs. 50.0% and 42.9%).

CONCLUSIONS

Our study demonstrated that decompression alone surgery was associated with significant improvement in disability in both groups at 2 years, but not in pain and quality of life in patients with SEL.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Wertli, Maria Monika

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0940-6719

Publisher:

Springer

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

29 Jun 2020 14:41

Last Modified:

16 May 2024 00:25

Publisher DOI:

10.1007/s00586-020-06449-w

PubMed ID:

32409888

Uncontrolled Keywords:

Lipomatosis Lumbar spine Spinal epidural lipomatosis Stenosis Surgical decompression

BORIS DOI:

10.7892/boris.144514

URI:

https://boris.unibe.ch/id/eprint/144514

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