Jörg, L.; Mueller‐Wirth, N.; Pecaric‐Petkovic, T.; Diaz, C.; Pichler, W.; Hausmann, O. (2020). The Fcε‐receptor I pathway is crucial but not exclusive for basophil activation in patients with autoimmune forms of chronic spontaneous urticaria. Journal of the European Academy of Dermatology and Venereology : JEADV, 34(12), e825-e827. Wiley 10.1111/jdv.16703
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Ibrutinib, an irreversible and specific Bruton's tyrosine kinase (BTK) inhibitor, leads to complete inhibition of IgE/FcεRI-BTK degranulation of human basophils without affecting the signaling via G-protein coupled receptors (C5a, fMLP) [1;2]. Since autoantibodies in chronic spontaneous urticaria (CSU) either against the IgE/FcεRI complex or IgE play a relevant role in CSU [3;4], ibrutinib could, therefore, be a promising asset in basophil assays [5]. This in-vitro study aimed to differentiate between FcεRI dependent and independent pathways in autoimmune CSU (aiCSU).
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology |
UniBE Contributor: |
Jörg, Lukas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-3083 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Lukas Jörg |
Date Deposited: |
29 Jun 2020 17:33 |
Last Modified: |
05 Dec 2022 15:39 |
Publisher DOI: |
10.1111/jdv.16703 |
PubMed ID: |
32491222 |
BORIS DOI: |
10.48350/144530 |
URI: |
https://boris.unibe.ch/id/eprint/144530 |
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