The Fcε‐receptor I pathway is crucial but not exclusive for basophil activation in patients with autoimmune forms of chronic spontaneous urticaria

Jörg, Lukas; Mueller‐Wirth, Nicole; Pecaric‐Petkovic, Tatjana; Diaz, Carolina; Pichler, Werner; Hausmann, Oliver (2020). The Fcε‐receptor I pathway is crucial but not exclusive for basophil activation in patients with autoimmune forms of chronic spontaneous urticaria (In Press). Journal of the European Academy of Dermatology and Venereology : JEADV Wiley 10.1111/jdv.16703

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Ibrutinib, an irreversible and specific Bruton's tyrosine kinase (BTK) inhibitor, leads to complete inhibition of IgE/FcεRI-BTK degranulation of human basophils without affecting the signaling via G-protein coupled receptors (C5a, fMLP) [1;2]. Since autoantibodies in chronic spontaneous urticaria (CSU) either against the IgE/FcεRI complex or IgE play a relevant role in CSU [3;4], ibrutinib could, therefore, be a promising asset in basophil assays [5]. This in-vitro study aimed to differentiate between FcεRI dependent and independent pathways in autoimmune CSU (aiCSU).

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Jörg, Lukas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1468-3083

Publisher:

Wiley

Submitter:

Lukas Jörg

Date Deposited:

29 Jun 2020 17:33

Last Modified:

30 Jun 2020 01:33

Publisher DOI:

10.1111/jdv.16703

PubMed ID:

32491222

URI:

https://boris.unibe.ch/id/eprint/144530

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