Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression

Koenig, Julian; Parzer, Peter; Haigis, Niklas; Liebemann, Jasmin; Jung, Tamara; Resch, Franz; Kaess, Michael (2019). Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression (In Press). Psychological medicine, pp. 1-10. Cambridge University Press 10.1017/S0033291719003490

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Background: Transcutaneous vagus nerve stimulation (tVNS) is a promising therapeutic option for major depressive disorder (MDD) in adults. Alternative third-line treatments for MDD in adolescents are scarce. Here we aimed to assess the effects of acute tVNS on emotion recognition in adolescents with MDD.

Methods: Adolescents (14-17 years) with MDD (n = 33) and non-depressed controls (n = 30) received tVNS or sham-stimulation in a cross-sectional, case-control, within-subject cross-randomized controlled trial, while performing different tasks assessing emotion recognition. Correct responses, response times, and errors of omission and commission on three different computerized emotion recognition tasks were assessed as main outcomes. Simultaneous recordings of electrocardiography and electro dermal activity, as well as sampling of saliva for the determination of α-amylase, were used to quantify the effects on autonomic nervous system function.

Results: tVNS had no effect on the recognition of gradually or static expressed emotions but altered response inhibition on the emotional Go/NoGo-task. Specifically, tVNS increased the likelihood of omitting a response toward sad target-stimuli in adolescents with MDD, while decreasing errors (independent of the target emotion) in controls. Effects of acute tVNS on autonomic nervous system function were found in non-depressed controls only.

Conclusions: Acute tVNS alters the recognition of briefly presented facial expressions of negative valence in adolescents with MDD while generally increasing emotion recognition in controls. tVNS seems to specifically alter early visual processing of stimuli of negative emotional valence in MDD. These findings suggest a potential therapeutic benefit of tVNS in adolescent MDD that requires further evaluation within clinical trials.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy

UniBE Contributor:

Koenig, Julian and Kaess, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0033-2917

Publisher:

Cambridge University Press

Language:

English

Submitter:

Chantal Michel

Date Deposited:

02 Jul 2020 17:08

Last Modified:

31 Jul 2020 03:33

Publisher DOI:

10.1017/S0033291719003490

PubMed ID:

31818339

BORIS DOI:

10.7892/boris.144669

URI:

https://boris.unibe.ch/id/eprint/144669

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