The Influence of Various Cerebral and Extracerebral Pathologies on Apparent Diffusion Coefficient Values in the Fetal Brain

Schönberg, Nadja; Weisstanner, Christian; Wiest, Roland; Bonél, Harald M.; Piechowiak, Eike I.; Cullmann, Jennifer L.; Raio, Luigi; Pastore-Wapp, Manuela; Slavova, Nedelina (2020). The Influence of Various Cerebral and Extracerebral Pathologies on Apparent Diffusion Coefficient Values in the Fetal Brain. Journal of neuroimaging, 30(4), pp. 477-485. Wiley 10.1111/jon.12727

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BACKGROUND AND PURPOSE: The changing MRI signal accompanying brain maturation in fetal brains can be quantified on apparent diffusion coefficient (ADC) maps. Deviations from the natural course of ADC values may reflect structural pathology. The purpose of this study was to determine the influence of fetal pathologies on the ADC values in different regions of the fetal brain and their evolution with increasing gestational age.

METHODS: This was a retrospective study of 291 fetuses evaluated between the 14th and the 40th week of gestation using diffusion-weighted imaging (DWI). Fetuses with normal MRI findings but sonographically suspected pathology or fetuses with abnormalities not affecting the brain were analyzed in the control group and compared to fetuses suffering from different pathologies like hydrocephalus/ventriculomegaly, brain malformations, infections, ischemia/hemorrhage, diaphragmatic hernias, and congenital heart disease. Pairwise ADC measurements in each side of the white matter (WM) of the frontal, parietal, and occipital lobes, in the basal ganglia and the cerebellum, as well as a single measurement in the pons were performed and were plotted against gestational age.

RESULTS: In the control group, brain maturation followed a defined gradient, resulting in lower ADC values in the most mature regions. Each disorder group experienced abnormal patterns of evolution of the ADC values over time deviating from the expected course.

CONCLUSIONS: The ADC values in different regions of the fetal brain and their evolution with increasing gestational age are influenced by pathologies compromising the cerebral maturation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Weisstanner, Christian; Wiest, Roland; Bonel, Harald Marcel; Piechowiak, Eike Immo; Cullmann, Jennifer; Raio, Luigi; Pastore-Wapp, Manuela and Slavova, Nedelina Bozhidarova

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology

ISSN:

1051-2284

Publisher:

Wiley

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

03 Jul 2020 17:25

Last Modified:

15 Jul 2020 01:33

Publisher DOI:

10.1111/jon.12727

PubMed ID:

32557916

Uncontrolled Keywords:

ADC brain cerebral pathologies fetal MRI maturation

BORIS DOI:

10.7892/boris.144780

URI:

https://boris.unibe.ch/id/eprint/144780

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