Microbial-host molecular exchange and its functional consequences in early mammalian life.

Ganal-Vonarburg, Stephanie C.; Hornef, Mathias W; Macpherson, Andrew J. (2020). Microbial-host molecular exchange and its functional consequences in early mammalian life. Science, 368(6491), pp. 604-607. American Association for the Advancement of Science 10.1126/science.aba0478

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Molecules from symbiotic microorganisms pervasively infiltrate almost every organ system of a mammalian host, marking the initiation of microbial-host mutualism in utero, long before the newborn acquires its own microbiota. Starting from in utero development, when maternal microbial molecules can penetrate the placental barrier, we follow the different phases of adaptation through the life events of birth, lactation, and weaning, as the young mammal adapts to the microbes that colonize its body surfaces. The vulnerability of early-life mammals is mitigated by maternal detoxification and excretion mechanisms, the protective effects of maternal milk, and modulation of neonatal receptor systems. Host adaptations to microbial exposure during specific developmental windows are critical to ensure organ function for development, growth, and immunity.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Ganal-Vonarburg, Stephanie Christine and Macpherson, Andrew

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Andrew Macpherson

Date Deposited:

24 Jun 2020 11:01

Last Modified:

24 Jun 2020 11:01

Publisher DOI:

10.1126/science.aba0478

PubMed ID:

32381716

BORIS DOI:

10.7892/boris.144819

URI:

https://boris.unibe.ch/id/eprint/144819

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