Breast Milk Modulates Transgenerational Immune Inheritance.

Zimmermann, Jakob; Macpherson, Andrew J. (2020). Breast Milk Modulates Transgenerational Immune Inheritance. Cell, 181(6), pp. 1202-1204. Cell Press 10.1016/j.cell.2020.05.030

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ROR-γt+ regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. find that the set-point for ROR-γt+ Tregs is non-genetically maternally inherited during a critical time window after birth through immunoglobulin A present in breast milk.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Zimmermann, Jakob and Macpherson, Andrew

ISSN:

0092-8674

Publisher:

Cell Press

Language:

English

Submitter:

Professor Andrew Macpherson

Date Deposited:

24 Jun 2020 10:19

Last Modified:

18 Feb 2021 11:37

Publisher DOI:

10.1016/j.cell.2020.05.030

PubMed ID:

32497500

BORIS DOI:

10.7892/boris.144821

URI:

https://boris.unibe.ch/id/eprint/144821

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