A circuit perspective on narcolepsy.

Adamantidis, A. R.; Schmidt, M. H.; Carter, M E; Burdakov, D; Peyron, C; Scammell, Thomas E (2020). A circuit perspective on narcolepsy. Sleep, 43(5) Oxford University Press 10.1093/sleep/zsz296

Preview

Text Adamantidis, 2020, A circuit perspective on narcolepsy.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (359kB) | Preview

The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease.

Interest & Impact

Downloads

147 since deposited on 06 Jul 2020
29 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item