A circuit perspective on narcolepsy.

Adamantidis, A. R.; Schmidt, M. H.; Carter, M E; Burdakov, D; Peyron, C; Scammell, Thomas E (2020). A circuit perspective on narcolepsy. Sleep, 43(5) Oxford University Press 10.1093/sleep/zsz296

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The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Adamantidis, Antoine Roger and Schmidt, Markus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1550-9109

Publisher:

Oxford University Press

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

06 Jul 2020 17:24

Last Modified:

26 Jul 2020 12:29

Publisher DOI:

10.1093/sleep/zsz296

PubMed ID:

31919524

Uncontrolled Keywords:

cataplexy hypocretins/orexins narcolepsy neural circuits

BORIS DOI:

10.7892/boris.145005

URI:

https://boris.unibe.ch/id/eprint/145005

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