Morel, Eric; Armand, Stéphane; Assal, Frédéric; Allali, Gilles (2020). Parkinsonian gait in aging: A feature of Alzheimer's pathology? (In Press). Experimental gerontology, 134(110905), p. 110905. Elsevier 10.1016/j.exger.2020.110905
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INTRODUCTION
Central neurological gait abnormalities (CNGA; i.e. frontal or parkinsonian) are frequently associated with neurodegenerative conditions in older adults, but their pathophysiological substrates remain poorly described. This cross-sectional study aims to assess the association between cerebrospinal fluid (CSF) Alzheimer's biomarkers and CNGA.
METHODS
CSF biomarkers (phosphor-tau, total tau and Aβ1-42) were measured in 52 patients with CNGA (77.33 ± 6.09 years; 28.8% female). Gait phenotypes were evaluated by two diagnosis-blinded assessors and classified as frontal gait, parkinsonian gait or other gait abnormalities.
RESULTS
Parkinsonian gait was significantly associated with a decreased CSF Aβ42 even after adjusting on age, gender, comorbidities and white matter changes (β: -0.32; 95% CI: [-340.6; -22.9]; p value: 0.026). Phosphor-tau and total tau were not associated with any other CNGA (i.e. frontal gait and other gait abnormalities).
DISCUSSION
Parkinsonian gait represents a gait phenotype of Alzheimer's pathology in patients with CNGA.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Morel, Eric |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0531-5565 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
07 Jul 2020 16:29 |
Last Modified: |
05 Dec 2022 15:39 |
Publisher DOI: |
10.1016/j.exger.2020.110905 |
PubMed ID: |
32135204 |
Uncontrolled Keywords: |
Alzheimer's disease Amyloidopathy Central neurological gait disorders Parkinsonian gait Parkinsonism |
BORIS DOI: |
10.7892/boris.145025 |
URI: |
https://boris.unibe.ch/id/eprint/145025 |
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