Parkinsonian gait in aging: A feature of Alzheimer's pathology?

Morel, Eric; Armand, Stéphane; Assal, Frédéric; Allali, Gilles (2020). Parkinsonian gait in aging: A feature of Alzheimer's pathology? (In Press). Experimental gerontology, 134(110905), p. 110905. Elsevier 10.1016/j.exger.2020.110905

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INTRODUCTION

Central neurological gait abnormalities (CNGA; i.e. frontal or parkinsonian) are frequently associated with neurodegenerative conditions in older adults, but their pathophysiological substrates remain poorly described. This cross-sectional study aims to assess the association between cerebrospinal fluid (CSF) Alzheimer's biomarkers and CNGA.

METHODS

CSF biomarkers (phosphor-tau, total tau and Aβ1-42) were measured in 52 patients with CNGA (77.33 ± 6.09 years; 28.8% female). Gait phenotypes were evaluated by two diagnosis-blinded assessors and classified as frontal gait, parkinsonian gait or other gait abnormalities.

RESULTS

Parkinsonian gait was significantly associated with a decreased CSF Aβ42 even after adjusting on age, gender, comorbidities and white matter changes (β: -0.32; 95% CI: [-340.6; -22.9]; p value: 0.026). Phosphor-tau and total tau were not associated with any other CNGA (i.e. frontal gait and other gait abnormalities).

DISCUSSION

Parkinsonian gait represents a gait phenotype of Alzheimer's pathology in patients with CNGA.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Morel, Eric

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0531-5565

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

07 Jul 2020 16:29

Last Modified:

30 Jul 2020 20:29

Publisher DOI:

10.1016/j.exger.2020.110905

PubMed ID:

32135204

Uncontrolled Keywords:

Alzheimer's disease Amyloidopathy Central neurological gait disorders Parkinsonian gait Parkinsonism

BORIS DOI:

10.7892/boris.145025

URI:

https://boris.unibe.ch/id/eprint/145025

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