Duration of Pre-Operative Antibiotic Treatment and Culture Results in Patients With Infective Endocarditis.

Gisler, Valentin; Dürr, Sarah; Irincheeva, Irina; Limacher, Andreas; Droz, Sara; Carrel, Thierry; Englberger, Lars; Sendi, Parham (2020). Duration of Pre-Operative Antibiotic Treatment and Culture Results in Patients With Infective Endocarditis. Journal of the American College of Cardiology, 76(1), pp. 31-40. Elsevier 10.1016/j.jacc.2020.04.075

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Bacterial growth in cultures of resected heart valves of patients with infective endocarditis (IE) is influenced by pre-operative antibiotic treatment (preop-AT).


This study sought to evaluate the time dependency of valve culture results (positive valve culture [PVC] vs. negative valve culture) on preop-AT.


A total of 352 IE episodes in 344 adult patients of our tertiary referral hospital were retrospectively investigated (2005 to 2016). The primary endpoint was PVC results. The study used a logistic additive model adjusted for bacterial species, the McCabe-Jackson classification, and the existence of foreign valve material as covariables.


The 231 included IE cases (187 [81%] men, median age 62 years, 153 [66%] native valves) comprised 58 (25%) PVC results and 173 (75%) negative valve culture results. A multivariable analysis adjusted for bacterial species, McCabe-Jackson classification, and valve type resulted in odds ratios for PVC of 6.35 (95% confidence interval [CI]: 1.94 to 20.78; p = 0.002) and 3.93 (95% CI: 1.57 to 9.84; p = 0.003) for Enterococcus spp. and Staphylococcus spp., respectively. Model-based odds ratios for PVC risk reduction in 2-day intervals of preop-AT ranged from 0.64 (95% CI: 0.61 to 0.68) at day 7 to 0.74 (95% CI: 0.70 to 0.78) at day 13 and 0.98 (95% CI: 0.93 to 1.02) at day 21.


In IE cases treated with valve surgery, Staphylococcus aureus and Enterococcus spp. were associated with valve culture growth. After 7 days of antibiotic treatment, the additional effect of preop-AT on valve culture results per 2-day interval was minor. Antibiotic treatment beyond 21 days had no influence on culture results.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Gisler, Valentin, Irincheeva, Irina, Limacher, Andreas, Droz, Sara Christine, Carrel, Thierry, Englberger, Lars, Sendi, Parham


600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology








Andrea Flükiger-Flückiger

Date Deposited:

07 Jul 2020 18:30

Last Modified:

05 Dec 2022 15:39

Publisher DOI:


PubMed ID:


Additional Information:

Engelberger and Sendi contributed equally to this work.

Uncontrolled Keywords:

cardiac valve cultures infective endocarditis pre-operative antibiotic treatment





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