Prediction of Cerebral Venous Thrombosis with a new clinical score and D-dimer levels.

Heldner, Mirjam R.; Zuurbier, Susanna M.; Li, Bojun; von Martial, Rascha; Meijers, Joost C. M.; Zimmermann, Rebekka; Volbers, Bastian; Jung, Simon; El-Koussy, Marwan; Fischer, Urs; Kohler, Hans P.; Schroeder, Verena; Coutinho, Jonathan M.; Arnold, Marcel (2020). Prediction of Cerebral Venous Thrombosis with a new clinical score and D-dimer levels. Neurology, 95(7), e898-e909. American Academy of Neurology 10.1212/WNL.0000000000009998

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To investigate prediction of cerebral venous thrombosis (CVT) by clinical variables and D-dimer levels.


This prospective multicentre study included consecutive patients with clinically possible CVT. On admission, patients underwent clinical examination, blood-sampling for D-dimers-measuring (ELISA-test), and MR-/CT-venography. Predictive value of clinical variables and D-dimers for CVT were calculated. A clinical score to stratify patients into groups with low, moderate, or high CVT risk was established using multivariate logistic regression.


CVT was confirmed in 25.8% (94/359) patients by neuroimaging. The optimal estimate of clinical probability was based on 6 variables: seizure(s) at presentation (4 points), known thrombophilia (4 points), oral contraception (2 points), duration of symptoms >6 days (2 points), worst headache ever (1 point) and focal neurological deficit at presentation (1 point) (AUC 0.889).We defined 0-2 points as low CVT probability (NPV 94.1%). 186 (51.8%) patients had a low probability score, of whom 11 (5.9%) had CVT. The frequency of CVT was 28.3% (34/120) in patients with a moderate (3-5 points) and 92.5% (49/53) in patients with a high (6-12 points) probability score. All low CVT probability patients with CVT had D-dimers >500µg/L. Predictive value of D-dimers for CVT for ≥675µg/l (best cut-off) vs. ≥500µg/l respectively was: Sens:77.7%/Spec:77%/NPV:90.7%/ACC:77.2% vs. Sens:89.4%/Spec:66.4%/NPV:94.6%/ACC:72.4%. To the clinical score added D-dimers >500µg/L resulted in the best CVT prediction score explored (at the cut-off≥6 points: Sens:83%/Spec:86.8%/NPV:93.5%/ACC:84.4%/AUC:0.937).


The proposed new clinical score in combination with D-dimers may be helpful for prediction of CVT as a pretest score;none of the CVT patients showed low clinical probability for CVT and D-dimers <500µg/L.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Experimentelle Hämostase

UniBE Contributor:

Heldner, Mirjam Rachel, Li, Bojun, von Martial, Rascha, Volbers, Bastian, Jung, Simon, El-Koussy, Marwan, Fischer, Urs Martin, Schröder, Verena, Arnold, Marcel


600 Technology > 610 Medicine & health




American Academy of Neurology




Martin Zbinden

Date Deposited:

07 Jul 2020 08:43

Last Modified:

02 Mar 2023 23:33

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