Reproducibility of animal research in light of biological variation

Voelkl, Bernhard; Altman, Naomi S.; Forsman, Anders; Forstmeier, Wolfgang; Gurevitch, Jessica; Jaric, Ivana; Karp, Natasha A.; Kas, Martien J.; Schielzeth, Holger; Van de Casteele, Tom; Würbel, Hanno (2020). Reproducibility of animal research in light of biological variation. Nature reviews. Neuroscience, 21(7), pp. 384-393. Springer Nature 10.1038/s41583-020-0313-3

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Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms’ responses to experimental treatments can vary with both genotype and environmental conditions. In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. We also present a road map towards better practices in view of improving the reproducibility of animal research.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute > Animal Welfare Division
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute

UniBE Contributor:

Völkl, Bernhard; Jaric, Ivana and Würbel, Hanno

Subjects:

600 Technology > 630 Agriculture

ISSN:

1471-003X

Publisher:

Springer Nature

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

14 Jul 2020 12:17

Last Modified:

08 Aug 2020 07:07

Publisher DOI:

10.1038/s41583-020-0313-3

PubMed ID:

32488205

BORIS DOI:

10.7892/boris.145122

URI:

https://boris.unibe.ch/id/eprint/145122

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