Non-water-excitation MR spectroscopy techniques to explore exchanging protons in human brain at 3 T.

Dziadosz, Martyna; Bogner, Wolfgang; Kreis, Roland (2020). Non-water-excitation MR spectroscopy techniques to explore exchanging protons in human brain at 3 T. Magnetic resonance in medicine, 84(5), pp. 2352-2363. Wiley 10.1002/mrm.28322

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PURPOSE

To develop localization sequences for in vivo MR spectroscopy (MRS) on clinical scanners of 3 T to record spectra that are not influenced by magnetization transfer from water.

METHODS

Image-selected in vivo spectroscopy (ISIS) localization and chemical-shift-selective excitation (termed I-CSE) was combined in two ways: first, full ISIS localization plus a frequency-selective spin-echo and second, two-dimensional (2D) ISIS plus a frequency-selective excitation and slice-selective refocusing. The techniques were evaluated at 3 T in phantoms and human subjects in comparison to standard techniques with water presaturation or metabolite-cycling. ISIS included gradient-modulated offset-independent adiabatic (GOIA)-type adiabatic inversion pulses; echo times were 8-10 ms.

RESULTS

The novel 2D and 3D I-CSE methods yield upfield spectra that are comparable to those from standard MRS, except for shorter echo times and a limited frequency range. On the downfield/high-frequency side, they yield much more signal for exchangeable protons when compared to MRS with water presaturation or metabolite-cycling and longer echo times.

CONCLUSION

Novel non-water-excitation MRS sequences offer substantial benefits for the detection of metabolite signals that are otherwise suppressed by saturation transfer from water. Avoiding water saturation and using very short echo times allows direct observation of faster exchanging moieties than was previously possible at 3 T and additionally makes the methods less susceptible to fast T2 relaxation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Dziadosz, Martyna and Kreis, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0740-3194

Publisher:

Wiley

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

14 Jul 2020 08:42

Last Modified:

01 Jul 2021 02:30

Publisher DOI:

10.1002/mrm.28322

Related URLs:

PubMed ID:

32602971

Uncontrolled Keywords:

amides brain downfield human magnetization exchange proton MR spectroscopy

BORIS DOI:

10.7892/boris.145135

URI:

https://boris.unibe.ch/id/eprint/145135

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