Primary Multivessel Occlusions Treated With Mechanical Thrombectomy: A Multicenter Analysis and Systemic Literature Review.

Kaesmacher, Johannes; Meyer, Lukas; Styczen, Hanna; Lobsien, Donald; Seker, Fatih; Piechowiak, Eike; Tan, Benjamin Y Q; Fischer, Sebastian; Clajus, Christin; Yeo, Leonard; Papanagiotou, Panagiotis; Kastrup, Andreas; Maegerlein, Christian; Wunderlich, Silke; Möhlenbruch, Markus A; Radbruch, Alexander; Gralla, Jan; Fiehler, Jens; Maus, Volker (2020). Primary Multivessel Occlusions Treated With Mechanical Thrombectomy: A Multicenter Analysis and Systemic Literature Review. Stroke, 51(9), e232-e237. American Heart Association 10.1161/STROKEAHA.120.029629

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BACKGROUND AND PURPOSE

Acute ischemic stroke caused by primary multivessel occlusions (pMVO) is a rare but devastating disease. Whether multi-target mechanical thrombectomy for pMVO is beneficial remains unknown.

METHODS

Multicenter retrospective review of patients treated with multi-target mechanical thrombectomy. The following pMVO sites were included: basilar artery, internal carotid artery, and middle cerebral artery (M1 and M2). Baseline characteristics were reported together with interventional technique, technical efficacy, and safety parameters. Clinical outcomes were evaluated applying the National Institutes of Health Stroke Scale and modified Rankin Scale. A systematic literature review was performed to summarize previous reports on pMVO mechanical thrombectomy.

RESULTS

Of 6081 patients screened, 21 patients met the inclusion criteria (0.35% [95% CI, 0.23%-0.53%]). In 70% (14/20) a cardioembolic cause was reported. A successful reperfusion of Thrombolysis in Cerebral Infarction scale score ≥2b was achieved in 95.2% (20/21) for the first and 76.1% (16/21) for the second target vessel. In those who survived the acute hospital stay (n=10/21), median admission National Institutes of Health Stroke Scale improved from 21 (interquartile range, 13-27) to 8 (interquartile range, 2-20) at discharge (P=0.006). Mortality was 60% (12/20) at 90 days and only 20% (4/20) of patients reached modified Rankin Scale score ≤2. Acceptable outcomes were almost exclusively observed in pMVO patients presenting with at least one M2 occlusion.

CONCLUSIONS

Multi-target mechanical thrombectomy for pMVOs is rarely performed; however, the procedure appears to be feasible and safe with high reperfusion rates for both occlusion sites. More than half of all treated patients deceased early and favorable outcomes may only be expected for pMVO patients including at least one M2 occlusion.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kaesmacher, Johannes; Piechowiak, Eike Immo and Gralla, Jan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1524-4628

Publisher:

American Heart Association

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

14 Jul 2020 17:33

Last Modified:

26 Aug 2020 01:32

Publisher DOI:

10.1161/STROKEAHA.120.029629

PubMed ID:

32654632

Uncontrolled Keywords:

cerebral infarction middle cerebral artery reperfusion stroke thrombectomy

BORIS DOI:

10.7892/boris.145173

URI:

https://boris.unibe.ch/id/eprint/145173

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