Exploring Bottom-Up Visual Processing and Visual Hallucinations in Parkinson's Disease with Dementia

Murphy, Nicholas; Killen, Alison; Gupta, Rajnish K; Graziadio, Sara; Rochester, Lynn; Firbank, Michael; Baker, Mark R.; Allan, Charlotte; Collerton, Daniel; Taylor, John-Paul; Urwyler, Prabitha (2021). Exploring Bottom-Up Visual Processing and Visual Hallucinations in Parkinson's Disease with Dementia (In Press). Frontiers in neurology, 11 Frontiers Media S.A. 10.3389/fneur.2020.579113

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Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear. Here we compared amplitude and latency patterns of reversal visual evoked potentials (VEPs) in healthy controls (n=21) and PDD patients (n = 34) with a range of VH severities. PDD patients showed increased N2 latency relative to controls, but patients reporting complex VH (n=17) did not demonstrate any relationship between VEP measurements and their hallucination severity as measured on the neuropsychiatric inventory hallucinations subscale (NPIHal) score. Our VEP findings support previous reports of declining visual system physiology in PDD. However, no notable major relationships between the integrity of the visual pathway and VH were found.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

UniBE Contributor:

Urwyler-Harischandra, Prabitha

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-2295

Publisher:

Frontiers Media S.A.

Language:

English

Submitter:

Angela Amira Botros

Date Deposited:

26 Jan 2021 16:51

Last Modified:

29 Jan 2021 01:31

Publisher DOI:

10.3389/fneur.2020.579113

BORIS DOI:

10.48350/145219

URI:

https://boris.unibe.ch/id/eprint/145219

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