Cognitive motor impairments and brain structure in schizophrenia spectrum disorder patients with a history of catatonia.

Dean, Derek J; Woodward, Neil; Walther, Sebastian; McHugo, Maureen; Armstrong, Kristan; Heckers, Stephan (2020). Cognitive motor impairments and brain structure in schizophrenia spectrum disorder patients with a history of catatonia. Schizophrenia research, 222, pp. 335-341. Elsevier 10.1016/j.schres.2020.05.012

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There is growing interest in understanding the behavioral and neural mechanisms of catatonia. Here, we examine cognition and brain structure in schizophrenia spectrum disorder (SSD) patients with a history of catatonia. A total of 172 subjects were selected from a data repository; these included SSD patients with (n = 43) and without (n = 43) a history of catatonia and healthy control subjects (n = 86). Cognitive functioning was assessed using the Screen for Cognitive Impairment in Psychiatry (SCIP) and brain structure was assessed using voxel-based morphometry (VBM) in the CAT12 toolbox. SSD patients with a history of catatonia showed worse performance on tests of verbal fluency and processing speed compared to SSD patients without such a history, even after controlling for current antipsychotic and benzodiazepine use. No differences were found between patients with and without a history of catatonia in terms of brain structure. Both patient groups combined showed significantly smaller grey matter volumes compared to healthy control subjects in brain regions consistent with prior studies, including the anterior cingulate, insular, temporal, and medial frontal cortices. The results highlight a cognitive-motor impairment in SSD patients with a history of catatonia. Challenges and limitations of examining brain structure in patients with a history of catatonia are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1573-2509

Publisher:

Elsevier

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

16 Jul 2020 08:15

Last Modified:

20 Oct 2020 01:32

Publisher DOI:

10.1016/j.schres.2020.05.012

PubMed ID:

32423702

Uncontrolled Keywords:

Brain structure Catatonia Cognition Processing speed Psychosis Schizophrenia Verbal fluency

BORIS DOI:

10.7892/boris.145222

URI:

https://boris.unibe.ch/id/eprint/145222

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