Resident macrophages acquire innate immune memory in staphylococcal skin infection

Feuerstein, Reinhild; Forde, Aaron James; Lohrmann, Florens; Kolter, Julia; Ramirez, Neftali Jose; Zimmermann, Jakob; Gomez de Agüero, Mercedes; Henneke, Philipp (2020). Resident macrophages acquire innate immune memory in staphylococcal skin infection. eLife, 9 eLife Sciences Publications 10.7554/eLife.55602

Preview

Other (article pdf) elife-55602-v1.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview

Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mj) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mj subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mj half-life, thereby limiting the duration of memory. In summary, resident dermal Mj are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.

Interest & Impact

Downloads

197 since deposited on 20 Jul 2020
55 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item