Resident macrophages acquire innate immune memory in staphylococcal skin infection

Feuerstein, Reinhild; Forde, Aaron James; Lohrmann, Florens; Kolter, Julia; Ramirez, Neftali Jose; Zimmermann, Jakob; Gomez de Agüero, Mercedes; Henneke, Philipp (2020). Resident macrophages acquire innate immune memory in staphylococcal skin infection. eLife, 9 eLife Sciences Publications 10.7554/eLife.55602

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Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mj) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mj subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mj half-life, thereby limiting the duration of memory. In summary, resident dermal Mj are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Zimmermann, Jakob

ISSN:

2050-084X

Publisher:

eLife Sciences Publications

Projects:

Projects 744257 not found.

Language:

English

Submitter:

Jakob Zimmermann

Date Deposited:

20 Jul 2020 09:43

Last Modified:

23 Jan 2021 18:37

Publisher DOI:

10.7554/eLife.55602

PubMed ID:

32639232

BORIS DOI:

10.7892/boris.145262

URI:

https://boris.unibe.ch/id/eprint/145262

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