Multiple FGF4 Retrocopies Recently Derived within Canids.

Batcher, Kevin; Dickinson, Peter; Maciejczyk, Kimberly; Brzeski, Kristin; Hadji Rasouliha, Sheida; Letko, Anna; Drögemüller, Cord; Leeb, Tosso; Bannasch, Danika (2020). Multiple FGF4 Retrocopies Recently Derived within Canids. Genes, 11(8) MDPI, Molecular Diversity Preservation International 10.3390/genes11080839

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Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves (Canis rufus). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Hadji Rasouliha, Sheida; Letko, Anna; Drögemüller, Cord and Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2073-4425

Publisher:

MDPI, Molecular Diversity Preservation International

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

31 Jul 2020 16:23

Last Modified:

31 Jul 2020 16:23

Publisher DOI:

10.3390/genes11080839

PubMed ID:

32717834

Uncontrolled Keywords:

Canis lupus familiaris FGF4 duplication pseudogene retrocopy retrogene retrotransposition

BORIS DOI:

10.7892/boris.145489

URI:

https://boris.unibe.ch/id/eprint/145489

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