The impact of roller pump‐assisted cardiotomy suction unit on hemolysis

Jahren, Silje Ekroll; Jenni, Hansjoerg; Rösch, Yannick; Arn, Rafael; Tevaearai, Hendrik; Obrist, Dominik; Carrel, Thierry; Erdoes, Gabor (2020). The impact of roller pump‐assisted cardiotomy suction unit on hemolysis (In Press). Artificial organs Wiley-Blackwell 10.1111/aor.13763

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Hemolysis in cardiac surgery is often related to the contact of blood with air or artificial surfaces. Variations of negative pressure in the suction cannulas may represent an additional factor. Limited data exist on the contribution of a roller pump‐assisted (RPA) cardiotomy suction unit to hemolysis. Elevation of free hemoglobin (fHb) following air suction (AS) or suction tip occlusion (STO) events of a pump‐assisted cardiotomy suction unit was investigated in a mock circuit filled with blood from slaughtered domestic pigs. AS‐associated hemolysis was measured over 240 minutes with 2 minutes of AS occurring every 10 minutes. STO‐associated hemolysis was analyzed over 80‐minute periods: configuration 1 (c1) comprised a cycle of 20 minutes (min) occlusion and 60 minutes RPA flow (20/60 minutes); c2 comprised 20 cycles of 1/3 minutes; c3 comprised 40 cycles of 0.5/1.5 minutes; and c4 comprised 80 cycles of 0.25/0.75 minutes. The AS setup did not lead to significant hemolysis after 2 (P = .97), 3 (P = .40) or 4 (P = .11) hours. The STO setup showed the greatest hemolysis (ΔfHb of 30 mg/dL) in c1 after 20 minutes. ΔfHb was different in c1 from all other configurations at 20 minutes (P < .0001) and 80 minutes (P < .05). Ex vivo generation of large negative pressures by STO events is the main cause of cardiotomy suction‐associated hemolysis. The clinical relevance of this mechanism needs further investigations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)

UniBE Contributor:

Jahren, Silje Ekroll; Jenni, Hansjoerg; Rösch, Yannick Pascal; Obrist, Dominik; Carrel, Thierry and Erdös, Gabor

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0160-564X

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Dr. Silje Ekroll Jahren

Date Deposited:

04 Aug 2020 16:17

Last Modified:

05 Aug 2020 01:33

Publisher DOI:

10.1111/aor.13763

PubMed ID:

32619302

BORIS DOI:

10.7892/boris.145565

URI:

https://boris.unibe.ch/id/eprint/145565

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