Estimation of additive and non-additive genetic effects for fertility and reproduction traits in North American Holstein cattle using genomic information.

Alves, Kristen; Brito, Luiz F.; Baes, Christine F.; Sargolzaei, Mehdi; Robinson, John Andrew B.; Schenkel, Flavio S. (2020). Estimation of additive and non-additive genetic effects for fertility and reproduction traits in North American Holstein cattle using genomic information. Journal of animal breeding and genetics, 137(3), pp. 316-330. Wiley-Blackwell 10.1111/jbg.12466

[img] Text
jbg.12466.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (492kB) | Request a copy

Non-additive genetic effects are usually ignored in animal breeding programs due to data structure (e.g., incomplete pedigree), computational limitations and over-parameterization of the models. However, non-additive genetic effects may play an important role in the expression of complex traits in livestock species, such as fertility and reproduction traits. In this study, components of genetic variance for additive and non-additive genetic effects were estimated for a variety of fertility and reproduction traits in Holstein cattle using pedigree and genomic relationship matrices. Four linear models were used: (a) an additive genetic model; (b) a model including both additive and epistatic (additive by additive) genetic effects; (c) a model including both additive and dominance effects; and (d) a full model including additive, epistatic and dominance genetic effects. Nine fertility and reproduction traits were analysed, and models were run separately for heifers (N = 5,825) and cows (N = 6,090). For some traits, a larger proportion of phenotypic variance was explained by non-additive genetic effects compared with additive effects, indicating that epistasis, dominance or a combination thereof is of great importance. Epistatic genetic effects contributed more to the total phenotypic variance than dominance genetic effects. Although these models varied considerably in the partitioning of the components of genetic variance, the models including a non-additive genetic effect did not show a clear advantage over the additive model based on the Akaike information criterion. The partitioning of variance components resulted in a re-ranking of cows based solely on the cows' additive genetic effects between models, indicating that adjusting for non-additive genetic effects could affect selection decisions made in dairy cattle breeding programs. These results suggest that non-additive genetic effects play an important role in some fertility and reproduction traits in Holstein cattle.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Baes, Christine Francoise

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

0931-2668

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Christine Francoise Baes

Date Deposited:

05 Aug 2020 08:24

Last Modified:

05 Aug 2020 08:24

Publisher DOI:

10.1111/jbg.12466

PubMed ID:

31912573

Uncontrolled Keywords:

breeding value dominance epistasis heritability non-additivity

BORIS DOI:

10.7892/boris.145575

URI:

https://boris.unibe.ch/id/eprint/145575

Actions (login required)

Edit item Edit item
Provide Feedback