Deficient processing of alcohol cues in the addicted brain: Evidence from event-related potential microstates.

Rohde, Kristina B.; Fey, Werner; Moggi, Franz; Koenig, Thomas; Luedi, Isabel; Duppenthaler, Lea; Stein, Maria (2020). Deficient processing of alcohol cues in the addicted brain: Evidence from event-related potential microstates. Clinical neurophysiology, 131(9), pp. 2224-2235. Elsevier 10.1016/j.clinph.2020.06.012

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OBJECTIVE

Patients with alcohol use disorder (AUD) show altered brain responses to alcohol cues as compared to healthy controls. Event-related potential (ERP) studies mostly focus on the P3, which is usually diminished in AUD patients. The few studies that have investigated earlier components have yielded inconsistent results. The present study aimed at identifying the onset of impaired alcohol cue processing in AUD patients, as well as the association between neurophysiological processing and subjective craving.

METHODS

A sample of 15 inpatients with AUD and 15 healthy controls completed a cue reactivity task with alcohol-related, neutral, and scrambled pictures. Multichannel-EEG was recorded from 70 scalp electrodes, and ERP microstates were analyzed.

RESULTS

Patients displayed impaired neurophysiological processing, as indexed by a weaker P3 and a weaker, insensitive P1. The blunted P1 was associated with higher subjective craving.

CONCLUSIONS

Impaired alcohol cue processing in AUD emerges early, at the stage of sensory processing. Such deficient initial processing seems crucial to understanding cue reactivity processes in the brain and in the subjective experience of craving.

SIGNIFICANCE

The results highlight the importance of investigating early ERP components preceding the P3, and contribute to the debate on the onset of information-processing dysfunction in the addicted brain.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

Rohde, Kristina Barbara; Fey, Werner Martin; Moggi, Franz; König, Thomas and Stein, Maria

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Kristina Barbara Rohde

Date Deposited:

05 Aug 2020 14:06

Last Modified:

19 Aug 2020 01:33

Publisher DOI:

10.1016/j.clinph.2020.06.012

PubMed ID:

32711347

Uncontrolled Keywords:

Alcohol cues Alcohol use disorder Cue reactivity ERPs Event-related potentials

BORIS DOI:

10.7892/boris.145602

URI:

https://boris.unibe.ch/id/eprint/145602

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