Efficacy of Dietary Supplements to Reduce Liver Fat.

Kilchoer, Brittanie; Vils, Anina; Minder, Beatrice; Muka, Taulant; Glisic, Marija; Bally, Lia (2020). Efficacy of Dietary Supplements to Reduce Liver Fat. Nutrients, 12(8), p. 2302. Molecular Diversity Preservation International MDPI 10.3390/nu12082302

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Liver fat accumulation is an important pathophysiological feature of non-alcoholic fatty liver disease that may be modulated by dietary supplements (DS). A systematic search of the literature was conducted for randomized controlled trials (RCTs) pertaining to the effect of a DS on liver fat as assessed using quantitative tomographic imaging in human adults. Where feasible, data were pooled, and meta-analyses conducted using random-effect model. Quality assessment was done according the Cochrane Collaboration's tool for assessing risk of bias. Twenty RCTs, involving 1171 overweight and obese adults, of which 36% were females, with or without comorbidities, were included. Only RCTs assessing omega-3 fatty acids (n = 4) and resveratrol (n = 4) qualified for meta-analysis. Results did neither favor omega-3 (effect size -1.17; weighted mean difference (WMD) (95% confidence interval (CI)) -3.62, 1.28; p < 0.001) nor resveratrol supplementation (0.18; 95% CI -1.08, 1.43; p = 0.27). The findings of the qualitatively summarized RCTs suggested that catechins (n = 1), Lactobacillus reuteri (n = 1), and carnitine (n = 1) may reduce liver fat. All other DS did not show any influence. The current evidence is scarce, of limited quality and does not support DS use to reduce liver fat. Further well-designed trials are warranted.

Item Type:

Journal Article (Original Article)


13 Central Units > Administrative Director's Office > University Library of Bern
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Minder, Beatrice, Muka, Taulant, Glisic, Marija, Bally, Lia Claudia


000 Computer science, knowledge & systems > 020 Library & information sciences
600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services




Molecular Diversity Preservation International MDPI




Andrea Flükiger-Flückiger

Date Deposited:

11 Aug 2020 20:03

Last Modified:

05 Dec 2022 15:39

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

computed tomography dietary supplements liver fat magnetic resonance imaging magnetic resonance spectroscopy non/alcoholic fatty liver disease





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