Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation.

Matter, Martin T; Li, Jian-Hao; Lese, Ioana; Schreiner, Claudia; Bernard, Laetitia; Scholder, Olivier; Hubeli, Jasmin; Keevend, Kerda; Tsolaki, Elena; Bertero, Enrico; Bertazzo, Sergio; Zboray, Robert; Olariu, Radu; Constantinescu, Mihai A.; Figi, Renato; Herrmann, Inge K (2020). Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation. Advanced science, 7(15), p. 2000912. Wiley 10.1002/advs.202000912

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Metal oxide nanoparticles have emerged as exceptionally potent biomedical sensors and actuators due to their unique physicochemical features. Despite fascinating achievements, the current limited understanding of the molecular interplay between nanoparticles and the surrounding tissue remains a major obstacle in the rationalized development of nanomedicines, which is reflected in their poor clinical approval rate. This work reports on the nanoscopic characterization of inorganic nanoparticles in tissue by the example of complex metal oxide nanoparticle hybrids consisting of crystalline cerium oxide and the biodegradable ceramic bioglass. A validated analytical method based on semiquantitative X-ray fluorescence and inductively coupled plasma spectrometry is used to assess nanoparticle biodistribution following intravenous and topical application. Then, a correlative multiscale analytical cascade based on a combination of microscopy and spectroscopy techniques shows that the topically applied hybrid nanoparticles remain at the initial site and are preferentially taken up into macrophages, form apatite on their surface, and lead to increased accumulation of lipids in their surroundings. Taken together, this work displays how modern analytical techniques can be harnessed to gain unprecedented insights into the biodistribution and biotransformation of complex inorganic nanoparticles. Such nanoscopic characterization is imperative for the rationalized engineering of safe and efficacious nanoparticle-based systems.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery

UniBE Contributor:

Lese, Ioana; Olariu, Radu and Constantinescu, Mihai Adrian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2198-3844

Publisher:

Wiley

Language:

English

Submitter:

Veronika Picha

Date Deposited:

13 Aug 2020 11:26

Last Modified:

16 Aug 2020 02:51

Publisher DOI:

10.1002/advs.202000912

PubMed ID:

32775166

Uncontrolled Keywords:

analytical imaging biological fate multiscale nanosafety spectral unmixing

BORIS DOI:

10.7892/boris.145805

URI:

https://boris.unibe.ch/id/eprint/145805

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