Ear type in sheep is associated with the MSRB3 locus.

Paris, J. M.; Letko, A.; Häfliger, I. M.; Ammann, P.; Drögemüller, C. (2020). Ear type in sheep is associated with the MSRB3 locus. Animal genetics, 51(6), pp. 968-972. Wiley 10.1111/age.12994

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Ear morphology is an important determinant of sheep breeds. It includes different variable traits such as ear size and erectness, suggesting a polygenic architecture. Here, we performed a comprehensive genome-wide analysis to identify regions under selection for ear morphology in 515 sheep from 17 breeds fixed for diverse ear phenotypes using 34k SNP genotyping data. GWASs for two ear type traits, size and erectness, revealed a single genome-wide significant association on ovine chromosome 3. The derived marker alleles were enriched in sheep with large and/or floppy ears. The GWAS signal harboured the MSRB3 gene encoding methionine sulphoxide reductase B3, which has already been found to be associated with different ear types in other species. We attempted whole-genome resequencing to identify causal variant(s) within a 1 Mb interval around MSRB3. This experiment excluded major copy number variants in the interval, but failed to identify a compelling candidate causal variant. Fine-mapping suggested that the causal variant for large floppy ears most likely resides in a 175 kb interval downstream of the MSRB3 coding region.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Paris, Julia Maria; Letko, Anna; Häfliger, Irene Monika and Drögemüller, Cord

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1365-2052

Publisher:

Wiley

Language:

English

Submitter:

Cord Drögemüller

Date Deposited:

01 Sep 2020 09:06

Last Modified:

06 Nov 2020 01:37

Publisher DOI:

10.1111/age.12994

PubMed ID:

32805068

Uncontrolled Keywords:

Ovis aries copy number variation fine-mapping genome-wide association study morphology whole-genome sequence

BORIS DOI:

10.7892/boris.146024

URI:

https://boris.unibe.ch/id/eprint/146024

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