Proton therapy and the European Particle Therapy Network: The past, present and future.

Weber, D.C.; Langendijk, J A; Grau, C; Thariat, J (2020). Proton therapy and the European Particle Therapy Network: The past, present and future. Cancer radiothérapie, 24(6-7), pp. 687-690. Elsevier Science 10.1016/j.canrad.2020.05.002

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Proton therapy is delivered to selected cancer patients presenting with rare tumours, for which a dose escalation paradigm and/or a reduced dose-bath to the organs at risk is pursued. It is a costly treatment with an additional cost factor of 2-3 when compared to photon radiotherapy. Notwithstanding the 180'000 patients treated with protons, scars robust clinical evidence is available to justify the administration of this treatment modality. The European Particle Therapy Network (EPTN) was created in 2015 to answer the critical European needs for cooperation among protons and carbon ions centres in the framework of clinical research networks. EPTN with other European groups will launch a number of prospective clinical trials that could be practice changing if positive. Alternative way to generate clinical data could be provided by alternative methodologies, such as the Dutch model-based approach, or could be provided by European infrastructure projects.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Weber, Damien Charles


600 Technology > 610 Medicine & health




Elsevier Science




Beatrice Scheidegger

Date Deposited:

25 Aug 2020 14:36

Last Modified:

25 Sep 2020 01:33

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cancer EPTN European research infrastructure European research networks Infrastructures de recherche européennes Proton therapy Protonthérapie Réseaux de recherche clinique européens




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