A comparison of the three year course between chronic depression and depression with multiple vs. few prior episodes

Humer, Elke; Kocsis-Bogar, Krisztina; Berger, Thomas; Schröder, Johanna; Späth, Christina; Meyer, Björn; Moritz, Steffen; Lutz, Wolfgang; Probst, Thomas; Klein, Jan Philipp (2020). A comparison of the three year course between chronic depression and depression with multiple vs. few prior episodes. Psychiatry research, 291, p. 113235. Elsevier 10.1016/j.psychres.2020.113235

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This study tested the hypothesis that chronic depression (CD) is more similar to depression with multiple prior episodes (ME) than to depression with few prior episodes (FE). Data from participants (n = 1013) with mild to moderate depressive symptoms (Patient Health Questionnaire [PHQ-9] score 5 – 14) who took part in a randomized control trial of an internet intervention for depression (EVIDENT trial) were re-analyzed. The MINI-interview was conducted to diagnose CD (n = 376). If CD was not diagnosed, the self-reported number of depressive episodes was used to categorize participants as having episodic depression with up to five (FE, n = 422) or more than five (ME, n = 215) prior episodes. Over a three-year period, participants were assessed repeatedly regarding the course of depression (PHQ-9, QIDS), quality of life (SF-12) and therapeutic progress (FEP-2). At baseline, most scores were different between CD and FE but comparable between CD and ME. Time to remission did not differ between CD and ME but was longer in CD compared to FE. Results suggest that ME closely resembles CD and that CD differs from FE.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Berger, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0165-1781

Publisher:

Elsevier

Language:

English

Submitter:

Melanie Best

Date Deposited:

25 Aug 2020 11:44

Last Modified:

13 Sep 2020 02:51

Publisher DOI:

10.1016/j.psychres.2020.113235

PubMed ID:

32599445

BORIS DOI:

10.7892/boris.146056

URI:

https://boris.unibe.ch/id/eprint/146056

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